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Enter location. The surgeons described the tissue as healthy bleeding smooth muscle surrounded by a tough collagen rind.

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The young man was reported to be pleased with Amdnia results, achieved erection without pain upon masturbation, but had no opportunity for sexual intercourse at the time of publication. The significance of the report is that little surgical information existed in the literature to guide the surgeons.

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The doctors were partly able to adopt techniques used to correct Peyronie's disease, where the penis is abnormally curved but without changes to its girth. Fir cell disease alone is serious and painful enough, affecting about 80, U.

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The disease results from two copies of the adult hemoglobin gene encoding amino acid changes that cause the resulting hemoglobin to form long strands in red blood cells, given them a sickle-like shape after they deliver oxygen to tissues. Looking for a Amenia dick red blood cells are short-lived and reduced in abundance, called anemia. The cells are also fragile and can damage the lining of tiny blood vessels, resulting in periodic, painful "crisis" episodes.

The young man's general medical history wasn't included in the paper but these crisis episodes cause repeated hospitalizations, particularly cor clots in the chest. The disease is routinely described as reducing life expectancy by 25 to 30 years. No cure exists for punm sex cell anemia.

Hydroxyurea, a simple small-molecule first discovered in duck, has been looking for a Amenia dick somewhat lookiing in sickle cell disease to reduce the number of crises requiring hospitalization and reducing the amount of normal blood transfusions necessary.

The drug, previously used to treat leukemias and other cancers, was only formally approved for sickle cell disease in It appears to active the production of a fetal form of hemoglobin and reduce damage to blood vessels. But how this young man's sickle cell disease led to his progressive, penile fibrosis is not entirely clear.

Sickle cell disease does increase the risk of priapism but the excessive fibrosis seen in this case has not been reported previously.

Individuals of African descent do, however, show a propensity toward scars, called keloids or hypertrophic scars, resulting from excessive collagen production.